Bryophytes: Hoard of remedies, an ethno-medicinal review (2024)

Abstract

Bryophytes are the second largest group of land plants after angiosperms. There is very less knowledge available about medicinal properties of these plants. Bryophytes are popular remedy among the tribal people of different parts of the world. Tribal people use these plants to cure various ailments in their daily lives. Bryophytes are used to cure hepatic disorders, skin diseases, cardiovascular diseases, used as antipyretic, antimicrobial, wound healing and many more other ailments by different tribal communities of Africa, America, Europe, Poland, Argentina, Australia, New Zealand, Turkey, Japan, Taiwan, Pakistan, China, Nepal and different parts of South, North and Eastern India. Apart from ethno-medicinal uses some bryophytes possesses antitumor activities against different cancer cell lines and this property of bryophytes needs to be more focused in the future. Compile information about medicinal properties and anticancer properties of bryophytes is lacking till date. In the present review, the authors tried to compile all the ethno-medicinal and other related information of bryophytes and fill the knowledge lacuna in this particular field. Some published reviews are available but the information is segregated. This manuscript will help people doing research in the bryophytes.

Keywords: Anti cancer, Hepatic disorder, Hornworts, Liverworts, Mosses

Graphical abstract

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1. Introduction

The division bryophytes include mosses (Bryopsida or Musci), hornworts (Anthocerotopsida or Anthocerotae) and liverworts (Hepaticopsida or Hepaticae) and represented by 14,000 to 15,000 species around the world. The mosses contains approximately 8000 species, liverworts 6000 species and hornworts 200 species.1 Some studies stated that these are the second largest group of land plants after angiosperms.2 In India, bryophytes represented by total 2504 species comprising 17.27% of world bryophytes. Among these, 642 species of bryophytes are endemic to India, showing 25.64% endemism. In India, mosses represented by 1786 species and 355 genera, liverworts 675 species and 121 genera and hornworts 25 species and 6 genera.3, 4 A total of 133 threatened species are reported from India and placed under rare category, out of these 78 species are mosses, 53 are liverworts and 2 are hornworts. Furthermore, 14 species from a different groups of bryophytes are recorded under the endangered category of threatened plants in India.5

Bryophytes play a remarkable role in maintaining ecosystems because they provide an important buffer system for other plants. As bryophytes do not have seeds or flowers hence they are placed under cryptogams. These plants are less known to most people due to the small size consequently less biomass made these plants neglected for wide use.6 They are found everywhere in the world from desert to ice cold polar region except seas. From the ancient times, bryophytes were used in packing, plugging as well as in decoration.

Bryophyte are used as indicator species, erosion control, bioindicators of heavy metals in air pollution, aquatic bioindicators, radioactivity indicators, as material for seed beds, fuel, medicines and food sources, pesticides, nitrogen fixation, moss gardening, treatment of waste, construction, clothing, furnishing, packing, genetic engineering and for soil conditioning and culturing.7, 8 The active constituents of bryophytes are widely used as antibacterial, antifungal, cytotoxic, antitumor and insecticidal9, 10 also in medicinal and agricultural areas.7, 11

The phytochemistry finding of bryophytes exhibit a greater range of biologically active compounds such as carbohydrates, lipid, protein, steroids, polyphenols, terpenoids, organic acids, sugar alcohols, fatty acids, aliphatic compounds, acetogenins, phenylquinones, and aromatic and phenolic substances which show significant bioactivities.12, 13

2. Material and methods

In the present review, information about bryophytes and their medicinal properties and biochemical properties was gathered via searching scientific databases including PubMed, Elsevier, Google Scholar, Springer etc. and related books either online or offline.

3. Aim of present review

Information about medicinal properties of bryophytes is segregated and not present in well documented form. In the present review, we have been trying to compile information regarding to medicinal properties and other related pharmacological properties of bryophytes.

4. Medicinal properties

4.1. Ethno-medicinal properties

An ancient method of determining the medicinal properties of plants is the concept of Paracelsus “doctrine of signatures” which deals with resemblence of plant body parts to shape and structure of organ in the human or animal body for which it is remedial. As per above philosophy, liverworts (e.g. Marchantia polymorpha) used to cure hepatic disorders.14 Similarly, Polytrichum commune bears hairy calyptra and called hair cup moss. The expressed oil from this moss was used by the women's of ancient time on their hair.8 Bryophytes adequately used in traditional Chinese medicinal system. Different ethnic groups of different parts of the world used these tiny plants to cure various ailments in their daily lives. The people of Gaddi tribes of Himachal Pradesh, India used Plagiochasma appendiculatum for treating skin diseases.15 The thalloid Targionia hypophylla used by Irular tribe of the Attappady valleys of Kerala state to cure skin diseases due to resembles of thallus of this liverwort to the rough surface of the diseased part. Due to long-stemmed and hair-like thallus of Frullania ericoides this liverwort is applied for hair-related afflictions by tribal people of South India.16 More information about ethno-medicinal uses of bryophytes is summarized in Table1.

Table1.

Ethano-medicinal properties of bryophytes.

Botanical nameFamilyUsesReferences
Liverworts
Riccardia Gray. sp.AneuraceaeUsed for anti-leukemic activity17, 18
Plagiochasma appendiculatum Lehm. & Lindenb.AytoniaceaeUsed in skin diseases (the fine paste of the thoroughly washed thalli is applied externally on affected area)17, 19
Reboulia hemisphaerica (L.) RaddAytoniaceaeUsed for blotches, hemostasis, external wounds, and bruises9
Conocephalum conicum (L.) Underw.ConocephalaceaeUsed as antimicrobial, antifungal, antipyretic, antidotal activity; used to treat cuts, swollen tissue, scalds, burns, fractures, poisonous snake bites, and gallstones17, 20
Herbertus Gray. sp.HerbertaceaeUsed as antiseptics, antidiarrheal agents, expectorants and astringents17, 18
Frullania tamarisci (L.) Dumort.JubulaceaeUsed for antiseptic activity9
Frullania ericoides (Nees ex Mart.) Mont.JubulaceaeUsed to get rid from head lice (Pediculus humanus) and nourishment of hair16
Marchantia polymorpha L.MarchantiaceaeThe thallus Paste applied externally on inflammation, used as diuretics, for liver ailments, insect bites, used to cure cuts, fractures, poisonous snake bites,18, 19, 21
Marchantia convoluta Gao et K.C. ZhangMarchantiaceaeUsed for treatment of hepatitis, fever and gastric intolerance22
Marchantia palmata NeesMarchantiaceaeFleshy leaf paste is directly applied during acute inflammation caused by the touch of fire and hot23
Marchantia paleacea Bertol.MarchantiaceaeUsed in skin tumefaction, hepatitis and as antipyretic24
Dumortiera hirsuta (Sw.) NeesMarchantiaceaeUsed as source for antibiotics18
Pallavicinia Gray. sp.PallaviciniaceaeUsed as antimicrobial agent18
Plagiochila (Dum.) Dum. sp.PlagiochilaceaeUsed for anti-leukemic activity/anti-microbial activity and used as perfumes or as perfume components17, 9
Plagiochila beddomei Steph.PlagiochilaceaeUsed for wound healing25
Riccia L. sp.RicciaceaeThe thallus is washed and ground to paste and mixed with jiggery and given to the children affected by the ringworms.19
Targionia hypophylla L.TargioniaceaeUsed with leaves of (Actiniopteris radiata) ground in to a paste and mixed with two tablespoons of coconut oil and smeared over the body of the children affected by scabies, itches and other skin diseases16
Mosses
Cratoneuron filicinum (Hedw.) SpruceAmblystegiaceaeUsed to treat heart disease9, 11
Leptodictyum riparium (Hedw.) Warnst.AmblystegiaceaeUsed as antipyritic and in uropathy11
Philonotis fontana (Hedw.) Brid.BartramiaceaeUsed to relieve pain of burn and heal burns, adenopharyngitis, antipyretic9, 11, 26
Philonotis Bridel sp.BartramiaceaeUsed to heal burns, for adenopharyngitis, as antipyretic and antidote9
Plagiopus oederi (Brid.) Limpr.BartramiaceaeUsed as sedative, epilepsy11
Bryum argenteum Hedw.BryaceaeUsed as antidote, antipyretic, antifungal9
Rhodobryum giganteum (Schwagr.) ParisBryaceaeUsed to treat cardiovascular problem and nervous prostration, to cure angina, anti-hypoxia, diuretic, antipyretic, and antihypertensive9, 11, 27
Rhodobryum roseum (Hedw.) Limpr.BryaceaeUsed to treat nervous prostration and cardiovascular diseases sedative9, 11, 28
Leucobryum bowringii Mitt.DicranaceaeDuring body pain, paste of leaf tips mixed in a cup of Phoenix sylvestris25
Oreas martiana (Hoppe and Hornsch.) Brid.DicranaceaeUsed for anodyne (pain), hemostasis, external wounds, epilepsy, menorrhagia, and neurasthenia (nervosism, nervous exhaustion)9
Ditrichum pallidum (Hedw.) HampeDitrichaceaeUsed for convulsions, particularly in infants9, 11
Entodon flavescens (Hook.) A. JaegerEntodontaceaeUsed during earache, leaf juice is used as ear drops, during cold, leaf juice is administered daily twice25
Fissidens nobilis Griff.= (Fissidens japonicus Dozy and Molk.)FissidentaceaeUsed for growth of hairs and diuretic activity11, 18
Funaria hygrometrica Hedw.FunariaceaeUsed for hemostasis, pulmonary tuberculosis, bruises, skin infection11
Fontinalis antipyretica Hedw.FontinalaceaeUsed in chest fever29
Taxiphyllum taxirameum (Mitt.) M. Fleisch.HypnaceaeUsed for external wounds, hemostasis9, 11
Aerobryum lanosum (Mitt.) Mitt.MeteoriaceaeUsed during burns, decoction of whole plant boiled in goat urine is applied externally25
Mnium cuspidatum Hedw.MniaceaeUsed for hemostasis, nose bleeding9, 11
Mnium Hedw. sp.MniaceaePoultice to reduce pain of burns, bruises and wounds18
Plagiomnium T. Kop. sp.MniaceaeUsed for infections and swellings18
Octoblepharum albidum Hedw.OctoblepharaceaeUsed as febrifuge and anodyne30
Dawsonia superba Grev.PolytrichaceaeUsed as diuretics, hair growth stimulation and for treating cold18
Polytrichum commune Hedw.PolytrichaceaeUsed for hemostasis, wound healer, antipyretic, antidotal activity, dissolve kidney and gall bladder stones, to speed up labor process during child birth11, 19, 20, 31, 32
Polytrichum juniperinum Hedw.PolytrichaceaeUsed to treat prostate, uninary difficulties and skin ailments8, 31
Pogonatum macrophyllum Dozy & Molk.PolytrichaceaeUsed to reduce inflammation and fever, also used as detergent diuretic, laxative and hemostatic agent17, 18
Barbula unguiculata Hedw.PottiaceaeUsed to treat fever and body aches18
Barbula indica (Hook.) Spreng.PottiaceaeUsed during menstrual pain and intermittent fever25
Hyophila attenuata Broth.PottiaceaeUsed during cold, cough and neck pain, leaf decoction is administered with a pinch of pepper powder daily25
Weisia viridula (L.) Hedw.PottiaceaeUsed to treat cold and fever9, 11
Sphagnum sericeum Mull. Hal.SphagnaceaeUsed to dressing wounds, with anti-microbial properties for skin ailments (insects bites, scabies, acne), haemorrhoids and to treat eye diseases18
Sphagnum teres (Schimp.) AngstromSphagnaceaeUsed to treat eye diseases8, 20
Haplocladium microphyllum (Hedw.) Broth.=(Haplocladium capillatum (Mitt.) Broth.)ThuidiaceaeUsed to treat cystisis, bronchitis, tonsillitis pneumonia and fever11, 20
Hornworts
Ceratophyllum demersum L.CeratophyllaceaeUsed as purgative, astringent, constipating and antipyratic33

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4.2. Anticancer properties

A number of naturally derived compounds act as an important source of several useful anti-cancer agents. Polytrichum commune used in Traditional Chinese Medicine (TCM) for curing diseases such as fever, hemostatic and traumatic injury to pneumonia, uterine prolapse and lymphocytic leukemia.34 Apart from this, the pharmacological exploration of acid and alcohol extract of Polytrichum juniperum exhibited inhibitory property against Sarcoma 37 implanted in CAF1 mice.35 The compound ohioensin A isolated from Polytrichum ohioense shows cytotoxicity against 9PS murine leukemia and MCF-7 human breast tumor cells. Benzonaphthoxanthenones and cinnamoyl bibenzyls derivatives isolated from ethanolic extract of Polytrichum pallidisetum can significantly impede the growth of RPMI-7951 melanoma and U-251glioblastoma multiforme.36 Bryophytes have great potential for anti-leukemia activity. Marchantin A from Marchantia palacea, M.polymorpha, and M.tosana, riccardin from Riccardia multifida, and perrottetin E from Radula perrottetii show cytotoxicity against the leukemic KB cells.37 The active constituent Diplophyllin, an ent-eudesmanolide isolated from liverworts Diplophyllum ablicans and D.taxifolium having α-methylene lactone unit showed significant anticancer activity against human epidermoid carcinoma.38 The Sesquiterpenoids costunolide and tulipinolide isolated from Frullania monocera, Marchantia polymorpha, Porella japonica, Wiesnerella denudate, Conocephalum supradecomositum and Plagiochila semidecurrens showed the anticancer activity against human carcinoma of the nasophaynx. The compound extracted from Plagiochilla fasciculatae seemed to inhibit P388cells (leukemia).39 It has been also suggested that mosses also retard the growth of cancer cell in culture.1 The mechanism of how bryophytes inhibit growth of different cancer cell lines and exhibit anticancer activity yet to be studied.

5. Other miscellaneous uses

The synthetic compound like pesticides, fungicides, rodenticides and insecticides are used commercially by the people that might have adverse effects on the environment and human health related issues. Apart from this, the concerted use of insecticides leads to increased resistance in insects.40, 41 Therefore, environment friendly and low toxicity new natural products are needed to provide alternatives to hazardous chemical that may otherwise alter the soil health and chemistry.

The use of bryophytes with insecticidal activity has gained importance over the past few years. Fatty acids derived from Hypnum cupressiforme, Dicranum scoparium, Polytrichastrum formosum, Homalothecium lutescens and liverwort Conocephalum conicum, used as insecticides against Sitophilus granaries. Likewise, the solution of moss powder of Calymperes afzelii, Thuidium gratum, Bryum coronatum and Barbula lambarenensis used against maize stem borers.42, 43 Several reports also confirmed the importance and activities of plants extract worked against insects44 fumigant45 contact46 repellent47 and antifeedant effects on stored product pests.48

Mosses like Bryum, Hypum and Fissidens growing in association with thallophytes in shallow waters of lakes, streams and spring contain huge amount of lime and act as rock builders. The insoluble calcium carbonate precipitates along with mosses and their symbionts aids in soil conservation. Developed countries like Sweden, West Germany, Finland, Poland, Ireland and Soviet Union uses hepaticae and musci as a source of fuel for generating natural gas, hydrogen, ethylene, methanol, etc. Among the mosses, peat mosses are the best sources of fuel for generation of heat, methane and have rapid regeneration, low sulfur content and their heating value is greater than that of wood.7 Bryophytes lack a leaf cuticle hence they are able to gain and loss water more quickly. Unlikehigherplants, these plants have the ability to absorb minute quantities of available moisture from fog, mist and dew that otherplants cannot utilize. The other uses of bryophytes like-liverworts and mosses as good indicators of environmental conditions, growth regulator (auxins, gibberellins, cytokinins and ethylene) and mosses as stuffing material.24

6. Negative impact of bryophytes

Few species of Frullania such as F.dilatata Dum., F.tamarisci Dum. F.tamarisci spp. nisquallensis, Chiloscyphus polyanthos and Schistochila appendiculata have been described as causative of potent allergic contact dermatitis because of containing a number of sesquiterpene lactones with an α-methylene γ-lacone functionality. These above mentioned species of Frullania also possess medicinal significance and growing epiphytically on the bark of trees, and hence have been recognized in areas of Canada, the United States, Finland and France as the cause of occupational contact dermatitis in forest workers, woodcutters and olive pickers.49, 50, 51 The allergens (+)-frullanolide and (−)-frullanolide are isolated from F.dilatata and F.tamarisci subsp. Tamarisci, respectively cause very intense allergenic contact dermatitis. The allergens of the Schistochila appendiculata are long-chain alkylphenols, 3-undecyl, 6-undecyl, 3-tridecyl, 3-pentadecyl, and 3-heptadecyl phenols, long-chain alkyl salicylic acids, 6-tridecyl, 6-pentadecyl salicylates, and their potassium salts, potassium 6-undecyl, 6-tridecyl, 6-pentadecyl salicylates and 6-undecyl catechol, also the cause of contact dermatitis problem.52Marchantia polymorpha and Metzgeria furcata also possess the allergenic contact dermatitis activity but their allergens still have not been isolated yet.37, 53

7. Conclusion

The data mentioned in Table1 containing 50 medicinal bryophytes which are very popular remedy among tribal people of different part of world. These tiny creatures are widely used by different tribal communities in Africa, America, Europe, Poland, Argentina, Australia, New Zealand, Turkey, Japan, Taiwan, Pakistan, China, Nepal and different parts of the South, North and East India. On the basis of Table1, it is concluded that major bryophytes used in hepatic disorders are liverworts apart from this; some species of moss are used in hepatic disorders. Some of the bryophytes species that are used in hepatic disorder are Frullania tamarisci, Reboulia hemisphaerica, Conocephalum conicum, Marchantia polymorha and mosses Sphagnum spp., Weissia controversa, Funaria hygrometrica, Bryum argenteum, Rhodobryum roseum, Climacium dendroides and Polytrichum commune. The peat moss species Sphagnum teres is very popular to treat various eye diseases in China. The moss Rhodobryum giganteum and R.roseum are widely used within China for cardiovascular disease and nervous prostrations. Polytrichum commune is used as an antipyretic, diuretic and hemostatic and Haplocaldium microphyllum is applied for tonsillitis, bronchitis, timpanists and cystitis. Despite the ethno-medicinal property Sphagnum spp. are used in surgical dressing because of better and faster absorption.

The plant derived natural products occupy an important place in the area of cancer chemotherapy because of minimal side effects. In this context Polytrichum commune play very significant role especially for the therapy of lymphocytic leukemia, Furthermore, it has been found that P.ohioense and P.pallidisetum also show cytotoxicity against the 9PS murine leukemia and several other tumor cell lines. Marchantia palacea, M.polymorpha, and M.tosana, Riccardia multifida, Radula perrottetii all show cytotoxicity against the leukemic KB cell.

8. Future prospective

Currenlty, scientific research on medicinal use of bryophytes is being carried out in most pharmaceutical laboratories, research institutes and universities. The current research is going on the active ingredients of medicinal bryophytes are used in curing diseases such as hepatic disorders, skin diseases, cardiovascular diseases, and many more other ailments. Another area of research is directed towards the discovery of new kinds of drugs from the medicinal bryophytes which have not been explored so far. The drugs obtained from the traditional medicine, like Ayurveda, Unani and Siddha system need to be further evaluated and validated more scientifically. The Council of Scientific and Industrial Research (CSIR), New Delhi, is involved in the validation of about 350 formulations of traditional medicines for different pharmacological activities.54 This new trend of evaluation and validation of traditional practices with modern knowledge provides significant opportunities for newer drug discoveries and would be an effective strategy for the improvement of human health care.

Disclosure/Conflict of interest statement

None of the authors of this paper has a financial or personal relationship with other people or organizations that could inappropriately influence or bias the content of the paper. It is to specifically state that “No Competing interests are at stake and there is No Conflict of Interest” with other people or organizations that could inappropriately influence or bias the content of the paper. The manuscript has not been published previously by any of the authors and/or is not under consideration for publication in another journal at the time of submission.

Footnotes

Peer review under responsibility of The Center for Food and Biomolecules, National Taiwan University.

Contributor Information

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References

  • 1.Hallingback T., Hodgetts N. vol. 53. World Conservation Union; 2000. (Mosses, Liverworts, and Hornworts. Status Survey and Conservation Action Plan for Bryophytes). [Google Scholar]
  • 2.Marko S., Aneta B., Dragoljub G. Bryophytes as a potential source of medicinal compounds. Pregl Rev. 2001;21:17–29. [Google Scholar]
  • 3.MoEF . Ministry of Environment and Forests, Govt. of India; New Delhi: 2014. India's Fifth National Report to the Convention on Biological Diversity. [Google Scholar]
  • 4.Sathish S.S., Kavitha R., Kumar S.S. Bryophytes in India-the current status. IJREB. 2013;1:22–31. [Google Scholar]
  • 5.Dandotiya D., Govindapyari H., Suman S., Uniyal P.L. Checklist of the bryophytes of India. Arch Bryol. 2011;88:1–126. [Google Scholar]
  • 6.Harris E.S. Ethnobryology: traditional uses and folk classification of bryophytes. Bryol. 2008;111:169–217. [Google Scholar]
  • 7.Saxena D.K., Harinder Uses of bryophytes. Resonance. 2004;9:56–65. [Google Scholar]
  • 8.Glime J.M. vol. 27. America Editorial Committee; Fl North America: 2007. pp. 14–41. (Economic and Ethnic Uses of Bryophytes). [Google Scholar]
  • 9.Asakawa Y. Biologically active compounds from bryophytes. Pure Appl Chem. 2007;79:557–580. [Google Scholar]
  • 10.Ucuncu O., Cansu T.B., Ozdemir T., Alpaykaraoglu S., Yayli N. Chemical composition and antimicrobial activity of the essential oils of mosses (Tortula muralis Hedw., Homalothecium lutescens (Hedw.) H. Rob., Hypnum cupressiforme Hedw, and Pohlianutans (Hedw.) Lindb. from Turkey. Turk J Chem. 2010;34:825–834. [Google Scholar]
  • 11.Pant G.P. Medicinal uses of bryophytes. In: Chopra R.N., editor. Topics in Bryology. Allied Publisher Limited; New Delhi: 1998. pp. 112–124. [Google Scholar]
  • 12.Pant G., Tewari S.D. Bryophytes and mankind. Ethnobotany. 1990;2:97–103. [Google Scholar]
  • 13.Asakawa Y. World Conference on Medicinal and Aromatic Plants Book of Abstracts (Vol. 86) 2001. Pharmacologically active substances from oriental bryophytes and inedible mushrooms and fijian kava. [Google Scholar]
  • 14.Miller N.G., Miller H. Make ye the bryophytes. Horticulture. 1979;57:40–47. [Google Scholar]
  • 15.Kumar K., Singh K.K., Asthana A.K., Nath V. Ethnotherapeutics of bryophyte Plagiochasma appendiculatum among the Gaddi tribes of Kangra valley, Himachal Pradesh, India. Pharm Biol. 2000;38:353–356. [Google Scholar]
  • 16.Remesh M., Manju C.N. Ethnobryological notes from Western Ghats, India. Bryol. 2009;112:532–537. [Google Scholar]
  • 17.Alam A. Some Indian bryophytes known for their biologically active compounds. Int Jappl Bio pharma Tech. 2012;3:239–246. [Google Scholar]
  • 18.Azuelo A.G., Sariana L.G., Pabualan M.P. Some medicinal bryophytes: their ethnobotanical uses and morphology. Asian J Biodiv. 2011;2:50–80. [Google Scholar]
  • 19.Shirsat R.P. Ethnomedicinal uses of some common bryophytes and pteridophytes used by tribals of Melghat region (Ms), India. Ethnobot Leafl. 2008;1:92. [Google Scholar]
  • 20.Ding H. Shanghai Science and Technology Press; Shanghai: 1982. Medicinal Spore-bearing Plants of China. [Google Scholar]
  • 21.Hu R. Higher Education Press; Beijing, China: 1987. Bryology; p. 465. [Google Scholar]
  • 22.Rao M. Ane book Pvt. Ltd; New Delhi: 2009. Microbes and Non-flowering Plants: Impact and Applications; pp. 213–214. [Google Scholar]
  • 23.Tag H., Das A.K., Loyi H. Anti-inflammatory plants used by the Khamti tribe of Lohit district in eastern Arunachal Pradesh, India. Nat Prod Radiance. 2007;6:334–340. [Google Scholar]
  • 24.Sabovljevic A., Sokovic M., Glamoclija J. Bio-activities of extracts from some axenically farmed and naturally grown bryophytes. JMed Plants Res. 2011;5:565–571. [Google Scholar]
  • 25.Lubaina A.S., Pradeep D.P., Aswathy J.M., Remya Krishnan M.K.V., Murugan K. Traditional knowledge of medicinal bryophytes by the kani tribes of Agasthiyarmalai biosphere reserve, southern western ghats. IAJPS. 2014;4:2116–2121. [Google Scholar]
  • 26.Flowers S. Ethnobryology of the Gosuite Indians of Utah. Bryologist. 1957;60:11–14. [Google Scholar]
  • 27.Wu P.C. Some uses of mosses in China. Bryol Times. 1982;13:5. [Google Scholar]
  • 28.Wu P.C. Rhodobryum giganteum (Schwaegr.) Par can be used for curing cardiovascular disease. Acta Phytotax Sin. 1977;15:93. [Google Scholar]
  • 29.Drobnik J., Stebel A. Medicinal mosses in pre-Linnaean bryophyte floras of central Europe. An example from the natural history of Poland. JEthnopharmacol. 2014;153:682–685. doi: 10.1016/j.jep.2014.03.025. [DOI] [PubMed] [Google Scholar]
  • 30.Singh A. CRC Press; New Delhi: 2011. Herbalism, Phytochemistry and Ethnopharmacology; pp. 286–293. [Google Scholar]
  • 31.Gulabani A. Bryophytes as economic plants. Botanica. 1974;14:73–75. [Google Scholar]
  • 32.Turner N.J., Thomas J., Carlson B.F., Ogilvie R.T. British Columbia Provincial Museum Occasional Paper Number 24, Victoria. British Columbia, Canada. 1983. Ethnobotany of the Nitinaht Indians of Vancouver Island. Victoria; p. 59. [Google Scholar]
  • 33.Pullaiah T. Dayabooks; New Delhi: 2006. Encyclopaedia of World Medicinal Plants (Vol. 1) pp. 513–514. [Google Scholar]
  • 34.Zhonghua, Bencao . Shanghai Science Technology Press; Shanghai: 1999. State Administration of Traditional Chinese Medicine of the People's Republic of China; pp. 22–23. [Google Scholar]
  • 35.Cheng X., Xiao Y., Wang X. Anti-tumor and pro-apoptotic activity of ethanolic extract and its various fractions from Polytrichum commune L. ex Hedw in L1210 cells. JEthnopharmacol. 2012;143:49–56. doi: 10.1016/j.jep.2012.05.054. [DOI] [PubMed] [Google Scholar]
  • 36.Zheng G.Q., Chang C.J., Stout T.J., Clardy J., Ho D.K., Cassady J.M. Ohioensins: novel benzonaphthoxanthenones from Polytrichum ohioense. JOrg Chem. 1993;58:366–372. [Google Scholar]
  • 37.Asakawa Y. Chemical constituents of the bryophytes. In: Herz W., Grisebach H., Kirby G.W., editors. vol. 42. Springer; Vienna: 1982. pp. 1–285. (Progress in the Chemistry of Organic Natural Products). [Google Scholar]
  • 38.Ohta Y., Andersen N.H., Liu C.B. Sesquiterpene constituents of two liverworts of genus Diplophyllum: novel eudesmanolides and cytotoxicity studies for enantiomeric methylene lactones. Tetrahedron. 1977;33:617–628. [Google Scholar]
  • 39.Asakawa Y. Biologically active substances obtained from bryophytes. JHattori Bot Lab. 1981;50:123–142. [Google Scholar]
  • 40.Alyokhin A., Baker M., Mota-Sanchez D., Dively G., Grafius E. Colorado potato beetle resistance to insecticides. Am J Pot Res. 2008;85:395–413. [Google Scholar]
  • 41.Whalon M.E., Mota–Sanchez D., Hollingworth R.M. 2012. The MSU Arthropod Pesticide Resistance Database. [Google Scholar]
  • 42.Abay G., Altun M., Karakoc O.C., Gul F., Demirtas I. Insecticidal activity of fatty acid-rich Turkish bryophyte extracts against Sitophilusgranarius (Coleoptera: Curculionidae) Com Chem High T Scr. 2013;16:806–816. doi: 10.2174/13862073113169990049. [DOI] [PubMed] [Google Scholar]
  • 43.Ande A.T., Wahedi J.A., Fatoba P.O. Biocidal activities of some tropical moss extracts against maize stem borers. Ethnobot Leafl. 2010;14:479–490. [Google Scholar]
  • 44.Polatoglu K., Karakoc O.C., Gokce A., Goren N. Insecticidal activity of Tanacetum hiliophyllum (Fisch. &Mey.) var. monocephalumgrierson extracts and a new sesquiterpene lactone. Phytochem Lett. 2011;4:432–435. [Google Scholar]
  • 45.Rajendran S., Sriranjini V. Plant products as fumigants for stored-product insect control. JStored Prod Res. 2008;44:126–135. [Google Scholar]
  • 46.Kim D.H., Ahn Y.J. Contact and fumigant activities of constituents of Foeniculumvulgare fruit against three coleopteran stored-product insects. Pest Manag Sci. 2001;57:301–306. doi: 10.1002/ps.274. [DOI] [PubMed] [Google Scholar]
  • 47.Papachristos D.P., Stamopoulos D.C. Repellent, toxic and reproduction inhibitory effects of essential oils vapours on Acanthoscelides obtectus (Say) (Coleoptera: Bruchidae) JStored Pro Res. 2002;38:117–128. [Google Scholar]
  • 48.Susurluk H., Caliskan Z., Gurkan O., Kirmizigul S., Goren N. Antifeedant activity of some Tanacetum species and bioassay guided isolation of the secondary metabolites of Tanacetum cadmium ssp cadmeum (Compositae) Ind Crop Prod. 2007;26:220–228. [Google Scholar]
  • 49.Mitchell J.C. Frullania (liverwort) phytodermatitis (woodcutter's eczema) Clin Dermatol. 1986;4:62–64. doi: 10.1016/0738-081x(86)90064-7. [DOI] [PubMed] [Google Scholar]
  • 50.Mitchell J.C., Fritig B., Singh B., Towers G.H.N. Allergic contact dermatitis from Frullania and compositae. The role of sesquiterpene lactones. JInvestig Dermatol. 1970;54:233–239. doi: 10.1111/1523-1747.ep12280310. [DOI] [PubMed] [Google Scholar]
  • 51.Knoche H., Ourisson G., Perold G.W., Foussereau J., Maleville J. Allergenic component of a liverwort: a sesquiterpene lactone. Science. 1969;166:239–240. doi: 10.1126/science.166.3902.239. [DOI] [PubMed] [Google Scholar]
  • 52.Asakawa Y. Highlights in phytochemistry of hepaticae-biologically active terpenoids and aromatic compounds. Pure Appl Chem. 1994;66:2193–2196. [Google Scholar]
  • 53.Asakawa Y., Ludwiczuk A., Nagashima F. Phytochemical and biological studies of bryophytes. Phytochem. 2013;91:52–80. doi: 10.1016/j.phytochem.2012.04.012. [DOI] [PubMed] [Google Scholar]
  • 54.Ratra M., Gupta R. Future prospects and aspects of herbal drug discovery in herbal medicines. Sciences. 2015;2:16–21. [Google Scholar]
Bryophytes: Hoard of remedies, an ethno-medicinal review (2024)

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